NOVEL STABLE CRYSTALS OF SUBSTITUTED PHENYLPROPIONIC ACID DERIVATIVE AND PROCESS FOR PRODUCING THE SAME

Preparation of (S)-2-[[3-[N-[4-[(4-fluorophenoxy)phenyl] methyl]carbamoyl]-4-methoxyphenyl]methyl]butanoic acid (referred to as compound (I)) on an industrial scale lies in the finding of homogeneous crystals with excellent stability and the establishment of a preparative process thereof. Novel crys...

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Hauptverfasser:	KOIKE, TOMOMI, ORITA, KAZUO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Preparation of (S)-2-[[3-[N-[4-[(4-fluorophenoxy)phenyl] methyl]carbamoyl]-4-methoxyphenyl]methyl]butanoic acid (referred to as compound (I)) on an industrial scale lies in the finding of homogeneous crystals with excellent stability and the establishment of a preparative process thereof. Novel crystals of compound (I) homogeneous and excellent in the stability characterized by exhibiting the diffraction angles (2.theta.) at least 17.7.degree., 19.0.degree. and 24.1.degree. in the X-ray powder diffraction are provided by recrystallizing from an alcoholic solvent.