PORE-FORMING AGENTS FOR ORTHOPEDIC CEMENTS
A bone precursor composition comprising a cement mixture and a pore-forming agent is provided for bone implant. Preferably, the pore-forming agent has a particle size of 20-500 .mu.m. More preferably, the proportion of the pore- forming agent is 7-40% (w/w). The composition may further include a bio...
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| creator | TOTH, CAROL ANN DALAL, PARESH S KULKARNI, SHAILESH C LANDERYOU, TRACY J |
| description | A bone precursor composition comprising a cement mixture and a pore-forming agent is provided for bone implant. Preferably, the pore-forming agent has a particle size of 20-500 .mu.m. More preferably, the proportion of the pore- forming agent is 7-40% (w/w). The composition may further include a bioactiv e agent, preferably a bone morphogenic protein or nucleic acid encoding BMP encapsulated in the pore-forming agent. The moldability of the composition c an be modulated by the addition of a binder. The invention provides a kit and implant device comprising the bone precursor composition. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region and a bone precursor material disposed on the surfac e region. The kit and devices may further comprise one or more additional components including a bioactive agent and a binder. Methods of inducing bon e formation and delivering the bioactive agent are provided. |
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Preferably, the pore-forming agent has a particle size of 20-500 .mu.m. More preferably, the proportion of the pore- forming agent is 7-40% (w/w). The composition may further include a bioactiv e agent, preferably a bone morphogenic protein or nucleic acid encoding BMP encapsulated in the pore-forming agent. The moldability of the composition c an be modulated by the addition of a binder. The invention provides a kit and implant device comprising the bone precursor composition. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region and a bone precursor material disposed on the surfac e region. The kit and devices may further comprise one or more additional components including a bioactive agent and a binder. Methods of inducing bon e formation and delivering the bioactive agent are provided.</description><edition>7</edition><language>eng ; fre</language><subject>AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G ; AGRICULTURE ; ANIMAL HUSBANDRY ; BANDAGES, DRESSINGS OR ABSORBENT PADS ; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES ; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES ; CHEMISTRY ; COMPOSITIONS BASED THEREON ; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS ; DIAGNOSIS ; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ; FILTERS IMPLANTABLE INTO BLOOD VESSELS ; FIRST-AID KITS ; FISHING ; FOMENTATION ; FORESTRY ; GENERAL PROCESSES OF COMPOUNDING ; HUMAN NECESSITIES ; HUNTING ; HYGIENE ; IDENTIFICATION ; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ; ORGANIC CHEMISTRY ; ORGANIC MACROMOLECULAR COMPOUNDS ; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES ; PEPTIDES ; PEST REPELLANTS OR ATTRACTANTS ; PLANT GROWTH REGULATORS ; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF ; PROSTHESES ; SURGERY ; THEIR PREPARATION OR CHEMICAL WORKING-UP ; TRAPPING ; TREATMENT OR PROTECTION OF EYES OR EARS ; WORKING-UP</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030327&DB=EPODOC&CC=CA&NR=2460843A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030327&DB=EPODOC&CC=CA&NR=2460843A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TOTH, CAROL ANN</creatorcontrib><creatorcontrib>DALAL, PARESH S</creatorcontrib><creatorcontrib>KULKARNI, SHAILESH C</creatorcontrib><creatorcontrib>LANDERYOU, TRACY J</creatorcontrib><title>PORE-FORMING AGENTS FOR ORTHOPEDIC CEMENTS</title><description>A bone precursor composition comprising a cement mixture and a pore-forming agent is provided for bone implant. Preferably, the pore-forming agent has a particle size of 20-500 .mu.m. More preferably, the proportion of the pore- forming agent is 7-40% (w/w). The composition may further include a bioactiv e agent, preferably a bone morphogenic protein or nucleic acid encoding BMP encapsulated in the pore-forming agent. The moldability of the composition c an be modulated by the addition of a binder. The invention provides a kit and implant device comprising the bone precursor composition. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region and a bone precursor material disposed on the surfac e region. The kit and devices may further comprise one or more additional components including a bioactive agent and a binder. Methods of inducing bon e formation and delivering the bioactive agent are provided.</description><subject>AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G</subject><subject>AGRICULTURE</subject><subject>ANIMAL HUSBANDRY</subject><subject>BANDAGES, DRESSINGS OR ABSORBENT PADS</subject><subject>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</subject><subject>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS</subject><subject>DIAGNOSIS</subject><subject>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</subject><subject>FILTERS IMPLANTABLE INTO BLOOD VESSELS</subject><subject>FIRST-AID KITS</subject><subject>FISHING</subject><subject>FOMENTATION</subject><subject>FORESTRY</subject><subject>GENERAL PROCESSES OF COMPOUNDING</subject><subject>HUMAN NECESSITIES</subject><subject>HUNTING</subject><subject>HYGIENE</subject><subject>IDENTIFICATION</subject><subject>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</subject><subject>ORGANIC CHEMISTRY</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES</subject><subject>PEPTIDES</subject><subject>PEST REPELLANTS OR ATTRACTANTS</subject><subject>PLANT GROWTH REGULATORS</subject><subject>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</subject><subject>PROSTHESES</subject><subject>SURGERY</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><subject>TRAPPING</subject><subject>TREATMENT OR PROTECTION OF EYES OR EARS</subject><subject>WORKING-UP</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2003</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAK8A9y1XXzD_L19HNXcHR39QsJVgByFfyDQjz8A1xdPJ0VnF19QcI8DKxpiTnFqbxQmptBwc01xNlDN7UgPz61uCAxOTUvtSTe2dHIxMzAwsTY0dCYCCUADNgkKw</recordid><startdate>20030327</startdate><enddate>20030327</enddate><creator>TOTH, CAROL ANN</creator><creator>DALAL, PARESH S</creator><creator>KULKARNI, SHAILESH C</creator><creator>LANDERYOU, TRACY J</creator><scope>EVB</scope></search><sort><creationdate>20030327</creationdate><title>PORE-FORMING AGENTS FOR ORTHOPEDIC CEMENTS</title><author>TOTH, CAROL ANN ; DALAL, PARESH S ; KULKARNI, SHAILESH C ; LANDERYOU, TRACY J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2460843A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2003</creationdate><topic>AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G</topic><topic>AGRICULTURE</topic><topic>ANIMAL HUSBANDRY</topic><topic>BANDAGES, DRESSINGS OR ABSORBENT PADS</topic><topic>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</topic><topic>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS BASED THEREON</topic><topic>DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS</topic><topic>DIAGNOSIS</topic><topic>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</topic><topic>FILTERS IMPLANTABLE INTO BLOOD VESSELS</topic><topic>FIRST-AID KITS</topic><topic>FISHING</topic><topic>FOMENTATION</topic><topic>FORESTRY</topic><topic>GENERAL PROCESSES OF COMPOUNDING</topic><topic>HUMAN NECESSITIES</topic><topic>HUNTING</topic><topic>HYGIENE</topic><topic>IDENTIFICATION</topic><topic>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</topic><topic>ORGANIC CHEMISTRY</topic><topic>ORGANIC MACROMOLECULAR COMPOUNDS</topic><topic>ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES</topic><topic>PEPTIDES</topic><topic>PEST REPELLANTS OR ATTRACTANTS</topic><topic>PLANT GROWTH REGULATORS</topic><topic>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</topic><topic>PROSTHESES</topic><topic>SURGERY</topic><topic>THEIR PREPARATION OR CHEMICAL WORKING-UP</topic><topic>TRAPPING</topic><topic>TREATMENT OR PROTECTION OF EYES OR EARS</topic><topic>WORKING-UP</topic><toplevel>online_resources</toplevel><creatorcontrib>TOTH, CAROL ANN</creatorcontrib><creatorcontrib>DALAL, PARESH S</creatorcontrib><creatorcontrib>KULKARNI, SHAILESH C</creatorcontrib><creatorcontrib>LANDERYOU, TRACY J</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TOTH, CAROL ANN</au><au>DALAL, PARESH S</au><au>KULKARNI, SHAILESH C</au><au>LANDERYOU, TRACY J</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PORE-FORMING AGENTS FOR ORTHOPEDIC CEMENTS</title><date>2003-03-27</date><risdate>2003</risdate><abstract>A bone precursor composition comprising a cement mixture and a pore-forming agent is provided for bone implant. Preferably, the pore-forming agent has a particle size of 20-500 .mu.m. More preferably, the proportion of the pore- forming agent is 7-40% (w/w). The composition may further include a bioactiv e agent, preferably a bone morphogenic protein or nucleic acid encoding BMP encapsulated in the pore-forming agent. The moldability of the composition c an be modulated by the addition of a binder. The invention provides a kit and implant device comprising the bone precursor composition. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region and a bone precursor material disposed on the surfac e region. The kit and devices may further comprise one or more additional components including a bioactive agent and a binder. Methods of inducing bon e formation and delivering the bioactive agent are provided.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G AGRICULTURE ANIMAL HUSBANDRY BANDAGES, DRESSINGS OR ABSORBENT PADS BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS BASED THEREON DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS DIAGNOSIS DISINFECTION, STERILISATION, OR DEODORISATION OF AIR FILTERS IMPLANTABLE INTO BLOOD VESSELS FIRST-AID KITS FISHING FOMENTATION FORESTRY GENERAL PROCESSES OF COMPOUNDING HUMAN NECESSITIES HUNTING HYGIENE IDENTIFICATION MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORGANIC CHEMISTRY ORGANIC MACROMOLECULAR COMPOUNDS ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES PEPTIDES PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF PROSTHESES SURGERY THEIR PREPARATION OR CHEMICAL WORKING-UP TRAPPING TREATMENT OR PROTECTION OF EYES OR EARS WORKING-UP |
| title | PORE-FORMING AGENTS FOR ORTHOPEDIC CEMENTS |
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