PORE-FORMING AGENTS FOR ORTHOPEDIC CEMENTS

A bone precursor composition comprising a cement mixture and a pore-forming agent is provided for bone implant. Preferably, the pore-forming agent has a particle size of 20-500 .mu.m. More preferably, the proportion of the pore- forming agent is 7-40% (w/w). The composition may further include a bio...

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Bibliographische Detailangaben
Hauptverfasser:	TOTH, CAROL ANN, DALAL, PARESH S, KULKARNI, SHAILESH C, LANDERYOU, TRACY J
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G AGRICULTURE ANIMAL HUSBANDRY BANDAGES, DRESSINGS OR ABSORBENT PADS BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS BASED THEREON DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS DIAGNOSIS DISINFECTION, STERILISATION, OR DEODORISATION OF AIR FILTERS IMPLANTABLE INTO BLOOD VESSELS FIRST-AID KITS FISHING FOMENTATION FORESTRY GENERAL PROCESSES OF COMPOUNDING HUMAN NECESSITIES HUNTING HYGIENE IDENTIFICATION MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORGANIC CHEMISTRY ORGANIC MACROMOLECULAR COMPOUNDS ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES PEPTIDES PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF PROSTHESES SURGERY THEIR PREPARATION OR CHEMICAL WORKING-UP TRAPPING TREATMENT OR PROTECTION OF EYES OR EARS WORKING-UP
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Beschreibung
Zusammenfassung:	A bone precursor composition comprising a cement mixture and a pore-forming agent is provided for bone implant. Preferably, the pore-forming agent has a particle size of 20-500 .mu.m. More preferably, the proportion of the pore- forming agent is 7-40% (w/w). The composition may further include a bioactiv e agent, preferably a bone morphogenic protein or nucleic acid encoding BMP encapsulated in the pore-forming agent. The moldability of the composition c an be modulated by the addition of a binder. The invention provides a kit and implant device comprising the bone precursor composition. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region and a bone precursor material disposed on the surfac e region. The kit and devices may further comprise one or more additional components including a bioactive agent and a binder. Methods of inducing bon e formation and delivering the bioactive agent are provided.