PEGYLATED AND DIGLYCOSYLATED ERYTHROPOIETIN

The invention provides an erythropoietin mutein having the in vivo biologica l activity of causing bone marrow cells to increase production of reticulocyte s and red blood cells, characterized by being N-glycosylated at Asn38 but not N- glycosylated at Asn24. Such muteins have improved pharmaceutica...

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Bibliographische Detailangaben
1. Verfasser:	TISCHER, WILHELM
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides an erythropoietin mutein having the in vivo biologica l activity of causing bone marrow cells to increase production of reticulocyte s and red blood cells, characterized by being N-glycosylated at Asn38 but not N- glycosylated at Asn24. Such muteins have improved pharmaceutical properties.