G-CSF CONJUGATES

Polypeptide conjugates with G-CSF activity comprising a polypeptide having at least one introduced lysine residue and at least one removed lysine residue compared to the sequence of human G-CSF, and which are conjugated to 2-6 polyethylene glycol moieties. The conjugates have a lowin vitro bioactivi...

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Bibliographische Detailangaben
Hauptverfasser: SCHAMBYE, HANS THALSGARD, HANSEN, CHRISTIAN KARSTEN, MIKKELSEN, JAN MOLLER, ANDERSEN, KIM VILBOUR, NISSEN, TORBEN LAUESGAARD
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:Polypeptide conjugates with G-CSF activity comprising a polypeptide having at least one introduced lysine residue and at least one removed lysine residue compared to the sequence of human G-CSF, and which are conjugated to 2-6 polyethylene glycol moieties. The conjugates have a lowin vitro bioactivity, a long in vivo half-life, a reduced receptor-mediated clearance, and provide a more rapid stimulation of production of white blood cells and neutrophils than non-conjugates recombinant human G-CSF.