ESSENTIAL AND IMPORTANT GENES OF PSEUDOMONAS AERUGINOSA AND THE USE THEREOF TO DESIGN OR IDENTIFY ANTIBACTERIAL AGENTS

ESSENTIAL AND IMPORTANT GENES OF PSEUDOMONAS AERUGINOSA AND THE USE THEREOF TO DESIGN OR IDENTIFY ANTIBACTERIAL AGENTS

The invention includes a database of candidate essential genes in Pseudomona s aeruginosa, as well as otherwise important genes that, when mutated, lead to a growth attenuated phenotype. Such genes and mutants of such genes are important for identifying antibacterial agents suitable for treating and...

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Bibliographische Detailangaben
Hauptverfasser: WARRENER, PAUL, MCLARNAN, JENNIFER, FOLGER, BRUCE KIM, HOU, KEVIN
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention includes a database of candidate essential genes in Pseudomona s aeruginosa, as well as otherwise important genes that, when mutated, lead to a growth attenuated phenotype. Such genes and mutants of such genes are important for identifying antibacterial agents suitable for treating and preventing Pseudomonas aeruginosa infections. The invention includes methods for confirming the essentiality or importance of candidate genes, as well as methods for utilizing those genes to screen for new antibacterial drugs. The invention also includes the antibacterial agents identified using the disclosed methods, as well as methods of using the same for treating and preventing Pseudomonas infection.