CARDIOVASCULAR SAFETY ASSAY

The present invention provides assays and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. Said assays and kits are based on the finding that the interaction of astemizole with the HERG potassium channel can be exploited to predict cardiotoxicity o...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: JURZAK, MIREK ROMAN, HEYLEN, GODELIEVE IRMA CHRISTINE MARIA, JANSSEN, CORNELUS GERARDUS MARIA, VAN ASSOUW, HENRICUS PETRUS MARTINUS MARIA
Format: Patent
Sprache:eng ; fre
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Beschreibung
Zusammenfassung:The present invention provides assays and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. Said assays and kits are based on the finding that the interaction of astemizole with the HERG potassium channel can be exploited to predict cardiotoxicity o f compounds during the development of new therapeutics and other agents.