MIXTURES OF INSULIN DRUG-OLIGOMER CONJUGATES COMPRISING POLYALKYLENE GLYCOL, USES THEREOF, AND METHODS OF MAKING SAME

MIXTURES OF INSULIN DRUG-OLIGOMER CONJUGATES COMPRISING POLYALKYLENE GLYCOL, USES THEREOF, AND METHODS OF MAKING SAME

A mixture of conjugates in which each conjugate in the mixture comprises an insulin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugates. The mixture may also be more ef...

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Hauptverfasser: ODENBAUGH, AMY L, PRICE, CHRISTOPHER H, ANSARI, ASLAM M, RADHAKRISHNAN, BALASINGAM, EKWURIBE, NNOCHIRI N
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:A mixture of conjugates in which each conjugate in the mixture comprises an insulin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugates. The mixture may also be more effective at surviving an in vitro model of intestinal digestion than polydispersed mixtures of similar conjugates. The mixture may also result in less inter-subject variability than polydispersed mixtures of similar conjugates. L'invention concerne un mélange de conjugués dans lequel chaque conjugué comprend un médicament à base d'insuline couplé à un oligomère comprenant une fraction de polyalkylène glycol. Ce mélange peut avoir une activité in vivo plus importante que celle d'un mélange polydispersé de conjugués similaires. De plus, ce mélange peut mieux survivre à la digestion intestinale dans un modèle in vitro que des mélanges polydispersés de conjugués similaires. Ce mélange peut également présenter une plus faible variabilité entre les sujets que les mélanges polydispersés de conjugués similaires.