NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS

Novel pyrrazole derivative compounds and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors. The disclosed invention relates to compounds of the structure (I) wherein (I) is a four, five, or six membered saturated ring and X is C, O or S.

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Bibliographische Detailangaben
Hauptverfasser:	MILLER, SHAWN CHRISTOPHER, SAWYER, JASON SCOTT, CIAPETTI, PAOLA, LI, HONG-YU, DECOLLO, TODD VINCENT, SMITH, EDWARD C. R, YINGLING, JONATHAN MICHAEL, HERRON, DAVID KENT, MCMILLEN, WILLIAM THOMAS, GOODSON, THEODORE JR, LIAO, JUNKAI, BEIGHT, DOUGLAS WADE, MORT, NICOLAS ANTHONY, GODFREY, ALEXANDER GLENN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Novel pyrrazole derivative compounds and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors. The disclosed invention relates to compounds of the structure (I) wherein (I) is a four, five, or six membered saturated ring and X is C, O or S.