METHOD FOR ISOLATING PHARMACEUTICALLY EXPLOITABLE ETIDRONATEDISODIUM

The invention relates to a method for isolating etidronate disodium. Accordi ng to said method, a liquid-liquid dispersion consisting of an aqueous-organic phase and an aqueous phase containing the etidronate disodium salt is set to a temperature of between 0 ~C and 30 ~C and is intensively mixed; a...

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Bibliographische Detailangaben
Hauptverfasser:	RATHE, HARALD, SCHMIDT, BARBARA, GRAWE, DETLEF
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The invention relates to a method for isolating etidronate disodium. Accordi ng to said method, a liquid-liquid dispersion consisting of an aqueous-organic phase and an aqueous phase containing the etidronate disodium salt is set to a temperature of between 0 ~C and 30 ~C and is intensively mixed; a coarse- grained fraction is subsequently precipitated out of the liquid-liquid dispersion and in a second, delayed step, a fine-grained fraction is precipitated out of the organic phase. The invention also relates to a novel solid form of etidronate disodium that can be obtained using this method. Th e invention provides a method for producing etidronate disodium with a particl e size in the region of 0.2 to 1.0 mm, good flowability and a high bulk densit y, coupled with properties that can be pharmaceutically exploited to advantage.