NAPHTHOSTYRILS

Disclosed are novel naphthostyrils of formula I. These compounds inhibit cyclin-dependent kinases (CDKs), in particular CDK2. These compounds and the ir pharmaceutically acceptable salts and esters are anti-proliferative agents useful in the treatment or control of cell proliferative disorders, in p...

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Bibliographische Detailangaben
Hauptverfasser:	LIU, JIN-JUN, DERMATAKIS, APOSTOLOS, KONZELMANN, FREDERICK MARTIN, CHEN, YI, LUK, KINUN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are novel naphthostyrils of formula I. These compounds inhibit cyclin-dependent kinases (CDKs), in particular CDK2. These compounds and the ir pharmaceutically acceptable salts and esters are anti-proliferative agents useful in the treatment or control of cell proliferative disorders, in particular cancer. Also disclosed are pharmaceutical compositions containing such compounds, methods for the treatment and/or prevention of cancer using such composition, and intermediates useful in the preparation of the compoun ds of formula I.