GENE EXPRESSION PROFILES ASSOCIATED WITH OSTEOBLAST DIFFERENTIATION

The present invention identifies genes whose expression pattern is altered when precursor stem cells undergo differentiation into osteoblasts. The gene s identified may be used as markers for the differentiation process. The prese nt invention also provides methods to screen agents that are capable...

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Bibliographische Detailangaben
Hauptverfasser:	HOUGHTON, ADAM, MERTZ, LAWRENCE, EINSTEIN, RICHARD, COOK, JONATHAN S, JAISWAL, NEELAM, AXELROD, DOUGLAS W, DARREN, JI
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING
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Beschreibung
Zusammenfassung:	The present invention identifies genes whose expression pattern is altered when precursor stem cells undergo differentiation into osteoblasts. The gene s identified may be used as markers for the differentiation process. The prese nt invention also provides methods to screen agents that are capable of modulating the differentiation process. The present invention also provides methods of identifying therapeutic agents that stimulate bone information by analyzing the expression of one or more of the genes identified.