CRYSTAL STRUCTURES OF RETAINING GLYCOSYLTRANSFERASES

The present invention relates to a crystal comprising the ligand binding pocket of a glycosyltransferase enzyme and optionally a donor molecule or analogue thereof and/or an acceptor molecule or analogue thereof. The presen t invention also relates to the use of such a crystal to identify ligands ca...

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Bibliographische Detailangaben
Hauptverfasser:	DIECKELMANN, MANUELA, WITHERS, STEPHEN G, WAKARCHUK, WARREN, STRYNADKA, NATALIE C.J, PERSSON, KARINA, LY, HOA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a crystal comprising the ligand binding pocket of a glycosyltransferase enzyme and optionally a donor molecule or analogue thereof and/or an acceptor molecule or analogue thereof. The presen t invention also relates to the use of such a crystal to identify ligands capable of modulating glycosyltransferase activity, and the use of such ligands in therapeutic applications.