NOVEL 2,3-BENZODIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

NOVEL 2,3-BENZODIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

The invention refers to novel 2,3-benzodiazepine derivatives of formula (I) and pharmaceutical compositions containing the same as the active ingredient. The novel compounds have antipasmodic, muscle relaxant and neuroprotective activities. In formula I; X represents a hydrogen atom, a chloro atom o...

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Bibliographische Detailangaben
Hauptverfasser: SZABO, GEZA, RATKAI, ZOLTAN, GIGLER, GABOR, SIMIG, GYULA, SZENASI, GABOR, MARTONNE MARKO, BERNADETT, LING, ISTVAN, GREFF, ZOLTAN, HARSING, LASZLO GABOR, VEGH, MIKLOS, LEVAY, GYORGY, BARKOCZY, JOZSEF
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention refers to novel 2,3-benzodiazepine derivatives of formula (I) and pharmaceutical compositions containing the same as the active ingredient. The novel compounds have antipasmodic, muscle relaxant and neuroprotective activities. In formula I; X represents a hydrogen atom, a chloro atom or a methoxy group; Y stands for a hydrogen atom or a halo atom; Z means a methyl group or a chloro atom; R is a C~1-4 alkyl group or a group of the formula -NR1~R~2, wherein R1~ and R2~ represent, independently, a hydrogen atom, a C~1-4 alkyl group, a C~1-4 alkoxy group or a C3-6~ cycloalkyl group.