PROCESS AND INTERMEDIATES FOR PREPARING ANTI-CANCER COMPOUNDS

Disclosed are methods for preparing compounds of the formula 9 and the pharmaceutically acceptable salts and solvates thereof, wherein R6 is alkyl or alkoxyalkyl; R7 is optionally substituted alkyl or optionally substituted alkylaryl; each R8, R9 and R10 are independently H, alkyl, halo, cyano, nitr...

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Bibliographische Detailangaben
Hauptverfasser:	SANTAFIANOS, DINOS PAUL, NORRIS, TIMOTHY, LEHNER, RICHARD SHELTON
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM AGRICULTURE ANIMAL HUSBANDRY APPARATUS THEREFOR BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY FERROUS OR NON-FERROUS ALLOYS FISHING FORESTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF PRETREATMENT OF RAW MATERIALS PRODUCTION AND REFINING OF METALS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRAPPING TREATMENT OF ALLOYS OR NON-FERROUS METALS
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Beschreibung
Zusammenfassung:	Disclosed are methods for preparing compounds of the formula 9 and the pharmaceutically acceptable salts and solvates thereof, wherein R6 is alkyl or alkoxyalkyl; R7 is optionally substituted alkyl or optionally substituted alkylaryl; each R8, R9 and R10 are independently H, alkyl, halo, cyano, nitro, trifluoromethyl, difluoromethoxy, trifluoromethoxy, azido,-OR11,-C(O)R11,-C (O)OR11, -NR12C(O)OR14,-OC(O)R11,-NR12SO2R14,-SO2NR11R12,-NR12C(O)R11, -C(O)NR11R12,-NR11R12, -S(O)j aryl, -S(O)j alkylaryl, -S(O)j alkyl, aryl, arylalkyl, aryloxy, arylalkoxy, arylamino, arylalkylamino, arylalkyl (alkyl) amino, heterocyclic or heterocyclic-alkyl, wherein j is 0 to 2; R11 is H, alkyl, aryl, arylalkyl, heterocyclic or heterocyclic-alkyl; R12 is H or unsubstituted alkyl and R14 is alkyl, aryl, arylalkyl, heterocyclic or heterocyclic-alkyl; and wherein the alkyl, aryl and heterocyclic groups may be substituted and the aryl and heterocyclic groups may be fused to an aryl, saturated cyclic group or heterocyclic group; and R15 is H, alkyl, aryl or alkylaryl. The foregoing compounds are useful in the treatment of hyperproliferative disorders, such as cancers, in mammals.