METHODS FOR PRODUCING NATEGLINIDE CRYSTALS

METHODS FOR PRODUCING NATEGLINIDE CRYSTALS

There is provided methods for producing nateglinide crystals, which comprises the steps of adding an acid(s) to a reaction mixture containing nateglinide to make it acidic, the reaction mixture being obtained by reacting trans-4-isopropylcyclohexylcarbonyl chloride with D-phenylalanine in a solvent...

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Bibliographische Detailangaben
Hauptverfasser: TAKAHASHI, SATOJI, TAKAHASHI, DAISUKE, NISHI, SEIICHI
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:There is provided methods for producing nateglinide crystals, which comprises the steps of adding an acid(s) to a reaction mixture containing nateglinide to make it acidic, the reaction mixture being obtained by reacting trans-4-isopropylcyclohexylcarbonyl chloride with D-phenylalanine in a solvent mixture comprising a ketone solvent and water, in the presence of an alkali; and then adjusting the temperature of the mixture to 58°C to 72°c and the concentration of ketone solvent to more than 8wt% and less than 22wt% to conduct precipitation of nateglinide crystals. This producing method is the industrially beneficial methods for crystallization of nateglinide.