PROCESS FOR MAKING 3-AMINO-2-CHLORO-4-METHYLPYRIDINE

An improved process for the preparation of 2-chloro-3-amino-4-methylpyridine (CAPIC) which comprises the following steps: (a) reacting acetylacetaldehyde dimethyl acetal with malononitrile to yield a mixture of 4,4-dicyano-3-methy l- 3-butenal dimethyl acetal and 1,1-dicyano-4-methoxy-2-methyl-1,3-b...

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Bibliographische Detailangaben
1. Verfasser:	GUPTON, BERNARD FRANKLIN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	An improved process for the preparation of 2-chloro-3-amino-4-methylpyridine (CAPIC) which comprises the following steps: (a) reacting acetylacetaldehyde dimethyl acetal with malononitrile to yield a mixture of 4,4-dicyano-3-methy l- 3-butenal dimethyl acetal and 1,1-dicyano-4-methoxy-2-methyl-1,3-butadiene, (b) treating the mixture of 4,4-dicyano-3-methyl-3-butenal dimethyl acetal a nd 1,1-dicyano-4-methoxy-2-methyl-1,3-butadiene so produced with a strong acid and water, to yield 3-cyano-4-methyl-2-pyridone, (c) treating the 3-cyano-4- methyl-2-pyridone with a strong chlorinating agent, to yield 3-cyano-2-chlor o- 4-methylpyridine, (d) treating the 3-cyano-2-chloro-4-methylpyridine with a strong acid and water, to yield 2-chloro-3-amido-4-methylpyridine, and (e) treating the 2-chloro-3-amido-4-methylpyridine with a strong base and a halide, to yield 2-chloro-3-amino-4-methylpyridine.