RECOMBINANT TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE WITH IMPROVED FUNCTIONALITY

Truncated terminal deoxynucleotidyl transferase (TdT) derivative from calf thymus characterized in that the derivative in comparison to the native TdT is N- terminally truncated by up to 161 amino acids and has a 20- 30-fold higher enzyme activity in solutions containing Co~ions, and it's recom...

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Hauptverfasser: SUPPMANN, BERNHARD, SCHNEIDINGER, BERND, SOBEK, HARALD, SCHMIDT, MANDFRED, MUELLER, RAINER, SONN, KIRSTEN, PAJATSCH, MARKUS, CURDT, INGO
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:Truncated terminal deoxynucleotidyl transferase (TdT) derivative from calf thymus characterized in that the derivative in comparison to the native TdT is N- terminally truncated by up to 161 amino acids and has a 20- 30-fold higher enzyme activity in solutions containing Co~ions, and it's recombinant production and use.