CROSS-LINKED HIGH AMYLOSE STARCH FOR USE IN CONTROLLED-RELEASE PHARMACEUTICAL FORMULATIONS AND PROCESSES FOR ITS MANUFACTURE

The present invention relates to a novel form of cross-linked high amylose starch and process for its manufacture. Such cross-linked high amylose starc h is useful as an excipient in a controlled-release pharmaceutical formulation when compressed with a pharmaceutical agent(s) in a tablet. Such cros...

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Bibliographische Detailangaben
Hauptverfasser:	HOPCKE, REINER, BECK, ROLAND HERWIG FRIEDRICH, BOGAERT, ELSIE VAN, LENAERTS, VINCENT, CHOUINARD, FRANCOIS, DESEVAUX, CYRIL
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G BABY COMFORTERS CHEMISTRY COMPOSITIONS BASED THEREON CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES DERIVATIVES THEREOF DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY DEVICES FOR RECEIVING SPITTLE DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS GENERAL PROCESSES OF COMPOUNDING HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP WORKING-UP
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Beschreibung
Zusammenfassung:	The present invention relates to a novel form of cross-linked high amylose starch and process for its manufacture. Such cross-linked high amylose starc h is useful as an excipient in a controlled-release pharmaceutical formulation when compressed with a pharmaceutical agent(s) in a tablet. Such cross-linke d high amylose starch is prepared by (a) cross-linking and chemical modificati on of high amylose starch, (b) gelatinization, and (c) drying to obtain a powde r of said controlled release excipient. In a preferred embodiment, such cross- linked high amylose starch is prepared in following steps: (1) granular cros s- linking and additionally chemical modification (e.g., hydroxypropylation) of high- amylose starch; (2) thermal gelatinization of the starch from step (1) ; and (3) drying the starch from step (2) to yield a powder capable of being used as a controlled release excipient.