INHIBITORS OF SERINE PROTEASES, PARTICULARLY HEPATITIS C VIRUS NS3 PROTEASE

INHIBITORS OF SERINE PROTEASES, PARTICULARLY HEPATITIS C VIRUS NS3 PROTEASE

The present invention relates to compounds that are useful as protease inhibitors, particularly as serine protease inhibitors, and more particularl y as hepatitis C NS3 protease inhibitors. As such, they act by interfering wit h the life cycle of the hepatitis C virus and are also useful as antivira...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: O'MALLEY, ETHAN, PERNI, ROBERT, COURT, JOHN, BHISETTI, GOVINDA RAO
Format: Patent
Sprache:eng ; fre
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The present invention relates to compounds that are useful as protease inhibitors, particularly as serine protease inhibitors, and more particularl y as hepatitis C NS3 protease inhibitors. As such, they act by interfering wit h the life cycle of the hepatitis C virus and are also useful as antiviral agents. This invention also relates to pharmaceutical compositions comprisin g these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HCV NS3 protease activity and consequently, may be advantageously used as therapeutic agents against the hepatitis C virus and other viruses that are dependent upon a serine protease for proliferation. This invention also relates to methods fo r inhibiting the activity of proteases, including hepatitis C virus NS3 protea se and other serine proteases, using the compounds of this invention and relate d compounds.