MANUFACTURE AND PURIFICATION OF CYCLOSPORIN A

The present invention provides an improved method for the manufacture of Cyclosporin A is disclosed. Cyclosporin A is produced by solid state fermentation of Fusarium solani in a bioreactor under optimal fermentation parameters. The product is extracted and further purified by treating with alum and...

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Bibliographische Detailangaben
Hauptverfasser:	ANAND, KONAYAKANAHALLI NANJUNDA SWAMY, GANESH, SAMBASIVAM, SURYANARAYAN, SHRIKUMAR, SUBRAMANIYAM, PAMPAPATHY, SIRCAR, ANINDYA, TAMBE, SHREEHAS, PRADEEP, KHEDKAR, ANAND, PRAKASH, RAMKRISHNA, MELARKODE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides an improved method for the manufacture of Cyclosporin A is disclosed. Cyclosporin A is produced by solid state fermentation of Fusarium solani in a bioreactor under optimal fermentation parameters. The product is extracted and further purified by treating with alum and subsequent chromatographic procedures to get pharmaceutical acceptable purity.