METHOD FOR THE PREPARATION OF FLUTICASONE AND RELATED 17BETA-CARBOTHIOIC ESTERS USING A NOVEL CARBOTHIOIC ACID SYNTHESIS AND NOVEL PURIFICATION METHODS

METHOD FOR THE PREPARATION OF FLUTICASONE AND RELATED 17BETA-CARBOTHIOIC ESTERS USING A NOVEL CARBOTHIOIC ACID SYNTHESIS AND NOVEL PURIFICATION METHODS

This invention discloses a method of conversion of carboxylic acids to carbothiotic acids by reacting a caarbpxylic acid with a first base, an iodi de salt, and a compound of formula (4) wherein the variables are as defined in the claims, and reacting the product with a hydrolysing agent and then wi...

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Bibliographische Detailangaben
Hauptverfasser: COOPER, ARTHUR J, LANGRIDGE, DENTON C, BARKALOW, JUFANG, CHAMBERLIN, STEVEN A, HUFNAGEL, JOHN, J, HOSSAIN, AZAD
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Beschreibung
Zusammenfassung:This invention discloses a method of conversion of carboxylic acids to carbothiotic acids by reacting a caarbpxylic acid with a first base, an iodi de salt, and a compound of formula (4) wherein the variables are as defined in the claims, and reacting the product with a hydrolysing agent and then with an acid. The method is applied to the preparation of androstane carbothiolates, such as fluticasone propionate, which avoids column chromatography.