2,4,DI(HETERO-)ARYLAMINO(-OXY)-5-SUBSTITUTED PYRIMIDINES AS ANTINEOPLASTIC AGENTS

Pyrimidine derivatives of formula (I) wherein Q1, Q2, G and R1 are as defined within; and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof are described. Processes for their manufacture , pharmaceutical compositions and their use as cyclin-dependent serine/threoni ne kinase...

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Hauptverfasser: PEARSON, STUART ERIC, BRADBURY, ROBERT HUGH, PEASE, ELIZABETH JANET, WILLIAMS, EMMA JANE
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:Pyrimidine derivatives of formula (I) wherein Q1, Q2, G and R1 are as defined within; and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof are described. Processes for their manufacture , pharmaceutical compositions and their use as cyclin-dependent serine/threoni ne kinase (CDK) and focal adhesion kinase (FAK) inhibitors are also described.< /SDOAB>