USE OF BIOACTIVE METABOLITES OF GEPIRONE FOR THE TREATMENT OF PSYCHOLOGICAL DISORDERS

Bioactive gepirone metabolites, such as 3-OH gepirone (4,4,-dimethyl-3-hydro xy- 1-[4-[4-(2-pyrimidinyl)-1-piper- azinyl]butyl]-2,6-piperidinedione), and their pharmaceutically acceptable salts and hydrates, can be used to alleviate psychological disorders or the symptoms thereof. The use of these c...

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Bibliographische Detailangaben
Hauptverfasser:	KRAMER, STEPHEN J, RUEDIGER, EDWARD H, FABRE, LOUIS F, YEVICH, JOSEPH P
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Bioactive gepirone metabolites, such as 3-OH gepirone (4,4,-dimethyl-3-hydro xy- 1-[4-[4-(2-pyrimidinyl)-1-piper- azinyl]butyl]-2,6-piperidinedione), and their pharmaceutically acceptable salts and hydrates, can be used to alleviate psychological disorders or the symptoms thereof. The use of these compounds provides advantages over other therapeutic azapirones as they possess superior bioavailability, faster onset of action, and more stable plasma levels when administered to a mammal.