DERIVATIVES OF POLYENE MACROLIDES AND PREPARATION AND USE THEREOF

The present invention provides a new class of polyene macrolide derivatives useful for treating or preventing fungal infections. The new polyene macroli de derivatives exhibit surprisingly superior antifungal activity and water solubility compared to amphotericin B methyl ester (AME). In addition, t...

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Bibliographische Detailangaben
Hauptverfasser:	BALDWIN, CHRISTOPHER J, CHANG, CONWAY CHENG, DANG, BINH T
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	The present invention provides a new class of polyene macrolide derivatives useful for treating or preventing fungal infections. The new polyene macroli de derivatives exhibit surprisingly superior antifungal activity and water solubility compared to amphotericin B methyl ester (AME). In addition, the n ew polyene macrolide derivatives have improved water solubility and lower toxicity than both amphotericin B (AmB) and AME.