PROCESS FOR THE PREPARATION OF AMORPHOUS ATORVASTATIN CALCIUM

The invention relates to a process for the preparation of amorphous atorvastatin calcium by recrystallization of crude atorvastatin from an organic solvent which comprises dissolving crude amorphous atorvastatin calcium in a lower alkanol containing 2-4 carbon atoms or a mixture of such alkanols und...

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Bibliographische Detailangaben
Hauptverfasser:	RATKAI, ZOLTAN, SIMIG, GYULA, BALAZS, LASZLO, VERECZKEYNE DONATH, GYORGYI, NAGY, KALMAN, KOTAY NAGY, PETER, SZENT KIRALLYI, ZSUZSA, GREFF, ZOLTAN, DOMAN, IMRE, BARTHA, FERENC, SERES, PETER, BARKOCZY, JOZSEF
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The invention relates to a process for the preparation of amorphous atorvastatin calcium by recrystallization of crude atorvastatin from an organic solvent which comprises dissolving crude amorphous atorvastatin calcium in a lower alkanol containing 2-4 carbon atoms or a mixture of such alkanols under heating and isolating the amorphous atorvastatin calcium precipitated after cooling. The atorvastatin calcium obtained is a known valuable agent useful in treating hyperlipidemia and hypercholesterolemia.