MICROELECTRONIC MOLECULAR DESCRIPTOR ARRAY DEVICES, METHODS, PROCEDURES, AND FORMATS FOR COMBINATORIAL SELECTION OF INTERMOLECULAR LIGAND BINDING STRUCTURES AND FOR DRUG SCREENING

These inventions relate to microelectronic molecular descriptor array device s, methods, procedures, and formats for combinatorial selection of intermolecul ar ligand binding structures and for drug screening. More particularly, those devices and methods rapidly carry out higher order selectivity of...

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Bibliographische Detailangaben
Hauptverfasser:	HELLER, MICHAEL J, ANDERSON, RICHARD R, ACKLEY, DONALD E, WINDHAB, NORBERT, HAMON, CHRISTIAN J, NOVA, TINA S, HOPPE, HANS-ULLRICH
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING THEIR RELEVANT APPARATUS TRANSPORTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	These inventions relate to microelectronic molecular descriptor array device s, methods, procedures, and formats for combinatorial selection of intermolecul ar ligand binding structures and for drug screening. More particularly, those devices and methods rapidly carry out higher order selectivity of combinatorially produced intermolecular ligand binding components, supramolecular structures and supramolecular complexes by application of unique stringency parameters. Preferably, the invention includes the formati on of exponential libraries by aggregation of sublibraries through the influenc e of electronic stringency to influence formation or detection of supramolecul ar structures or complexes. In addition, this invention relates to microelectronic array devices, procedures, methods and formats for molecular recognition processes, new drug discovery, generation of new affinity reagents, generation of synthetic antibodies, and for immunoassays.