SUSTAINED RELEASE DRUG DISPERSION DELIVERY DEVICE

The present invention is related to a drug delivery device, that is pH insensitive, for the sustained in situproduction and release of a dispersion, in an environment of use, which comprises a) a compressed core prepared from an admixture comprising i) a therapeutically effective amount of a benefic...

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Bibliographische Detailangaben
Hauptverfasser:	MCGLYNN, MICHAEL W, ASGHARNEJAD, MANDANA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention is related to a drug delivery device, that is pH insensitive, for the sustained in situproduction and release of a dispersion, in an environment of use, which comprises a) a compressed core prepared from an admixture comprising i) a therapeutically effective amount of a beneficial agent that has a solubility profile that is dependent on the pH level of the environment of use; ii) a water swellable polymer which upon hydration forms gelatinous microscopic particles; and iii) a pH modulator; a nd b) a water insoluble, water impermeable polymeric coating comprising a polym er and a plasticizer, which surrounds and adheres to the compressed core, said water insoluble, water impermeable polymeric coating having at least one aperture.