CRYSTAL STRUCTURE

The present invention relates to crystals of pyruvate dehydrogenase kinase (PDHK) wherein the PDHK protein includes PDHK-2 amino acid sequence as shown in SEQ ID NO: 2 but starting at amino acid position 16, or a homologue, fragment, variant or derivative thereof.). The invention also relates to hig...

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Bibliographische Detailangaben
Hauptverfasser:	ROBINSON, COLIN MARK, TUCKER, ALEXANDER DUNBAR, KNOECHEL, THORSTEN REGINALD, TAYLOR, WENDY ELAINE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to crystals of pyruvate dehydrogenase kinase (PDHK) wherein the PDHK protein includes PDHK-2 amino acid sequence as shown in SEQ ID NO: 2 but starting at amino acid position 16, or a homologue, fragment, variant or derivative thereof.). The invention also relates to high resolution three dimensional structures of PDHK in the presence and absence of physiological and syntheti c ligands obtained by X-ray diffraction and use of the structures to identify, design or select compounds that bind to PDHK. The invention further relates to compounds identified, designed or selected using high resolution structures of PDHK. Also provided are nucleotide sequences used to obtain crystallisable PDHK protein.