NEW PROCESS FOR THE PREPARATION OF N-(1,1-DIMETHYLETHYL)-4-[[5'-ETHOXY-4-CIS-[2-(4-MORFOLINO)ETHOXY]-2'-OXOSPIRO[CYCLOHEXAN-1,3'-[H]INDOL]-1'(2'H)-YL]-SULFONYL]-3-METHOXYBENZAMIDEAND ITS SALTS

NEW PROCESS FOR THE PREPARATION OF N-(1,1-DIMETHYLETHYL)-4-[[5'-ETHOXY-4-CIS-[2-(4-MORFOLINO)ETHOXY]-2'-OXOSPIRO[CYCLOHEXAN-1,3'-[H]INDOL]-1'(2'H)-YL]-SULFONYL]-3-METHOXYBENZAMIDEAND ITS SALTS

The invention relates to a process for the preparation of a compound of formula (I) and the salts thereof by reacting the compound of formula (II) with the compound of formula (III), which comprises carrying out the reaction in dimethyl sulfoxide, at a temperature between 10 .degree.C and 40 .degree...

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Bibliographische Detailangaben
Hauptverfasser: SZOMOR, TIBORNE, GONCZI, CSABA, SZVOBODA, GYORGYNE, SAROSI, PETER, HEJA, GERGELY, SANTANE CSUTOR, ANDREA, CSIKOS, EVA, MAJLATH, CSILLA, SIMON, KALMAN, NAGY, LAJOS, HERMECZ, ISTVAN, EROSNE TAKACSY, TUNDE POSA, HALASZ, JUDIT
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to a process for the preparation of a compound of formula (I) and the salts thereof by reacting the compound of formula (II) with the compound of formula (III), which comprises carrying out the reaction in dimethyl sulfoxide, at a temperature between 10 .degree.C and 40 .degree.C, preferably at room temperature and transforming the resulting base of formula (I), if desired, into its salt by a method known per se.