PEPTIDE CONJUGATES FOR THE STABILIZATION OF MEMBRANE PROTEINS AND INTERACTIONS WITH BIOLOGICAL MEMBRANES

PEPTIDE CONJUGATES FOR THE STABILIZATION OF MEMBRANE PROTEINS AND INTERACTIONS WITH BIOLOGICAL MEMBRANES

The present invention provides a novel class of detergents referred to herei n as lipopeptide detergents. Lipopeptide detergents comprise an amphipathic .alpha.-helical peptide having a hydrophobic or neutral face and a hydrophil ic face. To each end of this peptide is covalently linked an aliphatic...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser: PRIVE, GIL
Format: Patent
Sprache:eng ; fre
Schlagworte:
ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES
CANDLES
CHEMISTRY
DETERGENT COMPOSITIONS
DETERGENTS
FATTY ACIDS THEREFROM
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
RECOVERY OF GLYCEROL
RESIN SOAPS
SOAP OR SOAP-MAKING
USE OF SINGLE SUBSTANCES AS DETERGENTS
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Beschreibung
Zusammenfassung:The present invention provides a novel class of detergents referred to herei n as lipopeptide detergents. Lipopeptide detergents comprise an amphipathic .alpha.-helical peptide having a hydrophobic or neutral face and a hydrophil ic face. To each end of this peptide is covalently linked an aliphatic hydrocarbon tail, these aliphatic tails being linked thereto such that they associate with the hydrophobic or neutral face of the peptide. Lipopeptide detergents can advantageously be used to stabilize membrane proteins in the absence of a phospholipid bilayer in a manner that preserves the native conformation and permits the subsequent crystallization thereof.