METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGINGAMYLOID DEPOSITS USING ISOINDOLINE DERIVATIVES

METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGINGAMYLOID DEPOSITS USING ISOINDOLINE DERIVATIVES

The present invention provides a method of treating Alzheimer's disease usin g a novel compound of formula (I), wherein X is phenyl or substituted phenyl; Y is phenyl, substituted phenyl, pyridyl, or substituted pyridyl. Also provide d is a method of inhibiting the aggregation of amyloid protei...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LAI, YINGJIE, AUGELLI-SZAFRAN, CORINNE ELIZABETH, SAKKAB, ANNETTE THERESA, WALKER, LARY CRASWELL
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides a method of treating Alzheimer's disease usin g a novel compound of formula (I), wherein X is phenyl or substituted phenyl; Y is phenyl, substituted phenyl, pyridyl, or substituted pyridyl. Also provide d is a method of inhibiting the aggregation of amyloid proteins using a compou nd of formula (I) and a method of imaging amyloid deposits using isoindoline derivatives.