STEREOSELECTIVE MICROBIAL REDUCTION FOR THE PREPARATION OF 1-(4-FLUOROPHENYL)-3(R)-[3(S)-HYDROXY-3-(4-FLUOROPHENYL)PROPYL)]-4(S)-(4-HYDROXYPHENYL)-2-AZETIDINONE

STEREOSELECTIVE MICROBIAL REDUCTION FOR THE PREPARATION OF 1-(4-FLUOROPHENYL)-3(R)-[3(S)-HYDROXY-3-(4-FLUOROPHENYL)PROPYL)]-4(S)-(4-HYDROXYPHENYL)-2-AZETIDINONE

A process for the stereoselective microbial reduction of compound of formula (II) to compound of formula (I) comprising adding compound of formula (II) to a medium, medium and buffer, medium and solvent, or medium and a mixture of buffer and solvent containing a microorganism, preferably Rhodococcus...

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Bibliographische Detailangaben
Hauptverfasser: HOMANN, MICHAEL J, PREVITE, EDWARD
Format: Patent
Sprache:eng ; fre
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PROCESSES USING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:A process for the stereoselective microbial reduction of compound of formula (II) to compound of formula (I) comprising adding compound of formula (II) to a medium, medium and buffer, medium and solvent, or medium and a mixture of buffer and solvent containing a microorganism, preferably Rhodococcus fascians ATCC No.202210 or fungal isolate Geotrichum candidum ATCC No. 74487, incubating the resulting mixture, and isolating a hydroxy compound of formula (I), is described. The compound of formula (I) is a serum cholesterol lowering agent.