(1-PHENACYL-3-PHENYL-3-PIPERIDYLETHYL) PIPERIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

(1-PHENACYL-3-PHENYL-3-PIPERIDYLETHYL) PIPERIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

The invention relates to compounds of formula (I) and to the salts thereof with mineral or organic acids, the solvates and/or hydrates thereof, exhibiting a high affinity and high selectivity with respect to human NK1 receptors of substance P. The invention also relates to a method for the productio...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PROIETTO, VINCENZO, GUEULE, PATRICK, EMONDS-ALT, XAVIER, DUCOUX, JEAN PHILIPPE
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to compounds of formula (I) and to the salts thereof with mineral or organic acids, the solvates and/or hydrates thereof, exhibiting a high affinity and high selectivity with respect to human NK1 receptors of substance P. The invention also relates to a method for the production thereof, intermediate compounds of formula (VII) useful in the production thereof, pharmaceutical compositions containing said products and the use thereof in the production of medicaments to treat all pathologies involving substance P and NK1 human receptors.