ANTIBODIES AND FV FRAGMENT RECOGNIZING ANTIGEN IOR C2

The invention relates to the obtention of novel recombinant antibodies of novel recombinant antibodies from murine antibody ior C5 produced by the hybridome deposited under number ECCC 97061101 in accordance with the Budape st Treaty. Said recombinant antibodies were obtained using recombinant DNA t...

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Hauptverfasser:	BELL GARCIA, HANSSEL, DUENAS PORTO, MARTA, MATEO DE ACOSTA DEL RIO, CRISTINA MARIA, GAVILONDO COWLEY, JORGE VICTOR, MORALES MORALES, ALEJO, RAMOS ZUZARTE, MAYRA, IZNAGA ESCOBAR, NORMANDO, AYALA AVILA, MARTA, RENGIFO CALZADO, ENRIQUE, ROQUE NAVARRO, LOURDES TATIANA, PEREZ RODRIGUEZ, ROLANDO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to the obtention of novel recombinant antibodies of novel recombinant antibodies from murine antibody ior C5 produced by the hybridome deposited under number ECCC 97061101 in accordance with the Budape st Treaty. Said recombinant antibodies were obtained using recombinant DNA technology and are characterized in that they recognize antigen ior C2. The recombinant antibodies are specifically chimeric antibody, humanized antibod y and the single-chain Fv fragment. The chimeric antibody contains variable domains of murine immunoglobuline and the constant regions of human immunoglobuline. The humanized antibody contains the constant regions of hum an immunoglobuline and has been specifically modified in the murine framework regions (FRs) and within the latter, in those areas that may result in an antigenic site for cells T. The Fv fragment contains the variable domains of murine immunoglobuline. The invention also relates to the utilization of recombinant antibodies derived from murine antibody ior C5 in the diagnosis and therapy of colorectal tumors, the metastasis thereof and recurrences.