S-NITROSOTHIOLS AS AGENTS FOR THE TREATMENT OF CIRCULATORY DYSFUNCTIONS

Novel S-nitrosothiols derivatives of penicillamine or glutathione, which correspond to following general formula(I) (see formula I) in which: A and B are phenyl groups or together form the rest -CH2-Q-CH2- constituting a ring of six units in which Q represents an atom of oxygen, of sulfur, or a group N-R3, in which R3 is hydrogen or an alkyl group C1-C4; R1 is an acyl rest, which may be an aliphatic acyl group C1-C5 or a rest of glutamic acid bound via its non amino acid carboxyl; R2 is a hydroxyl group or a glycine rest bound via a peptide bond; with the proviso that if R1 is an aliphatic acyl rest then R2 is a hydroxyl group, and if R1 is a rest of glu-tamic acid then R2 is a glycine rest. The novel compounds have vasodilating activity arid inhibit the aggregation of the platelets, which make them useful for the treatment of dysfunctions of the cir-culatory system, specially at cardiovascular level.