PAIN CONTROL AGENT

Remedies for pain which contain as the active ingredient compounds having bo th of an opioid .mu. receptor agonist activity and a dopamine D2 receptor antagonist activity. The compounds having both of these activities exert a potent morphine-like analgetic effect but cause no mental dependency. More...

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Bibliographische Detailangaben
Hauptverfasser: TSUSHIMA, MASAKI, WATANABE, TAKASHI, MIIKE, NAOKO, ASAI, KENJI, YANAGISAWA, YUMIKO, AKIYAMA, YOSHIHISA, MORI, TOMOHISA, HIRANUMA, TOYOKAZU, KUDOU, TOSHIAKI
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:Remedies for pain which contain as the active ingredient compounds having bo th of an opioid .mu. receptor agonist activity and a dopamine D2 receptor antagonist activity. The compounds having both of these activities exert a potent morphine-like analgetic effect but cause no mental dependency. Moreover, these compounds can regulate side effects. In particular, novel compounds represented by general formula (I) and pharmacologically acceptabl e salts thereof have both of the opioid .mu. receptor agonist activity and the dopamine D2 receptor antagonist activity and are useful as remedies for pain with regulated side effects.