METHOD FOR PRODUCING L-PHENYLEPHRINE HYDROCHLORIDE

METHOD FOR PRODUCING L-PHENYLEPHRINE HYDROCHLORIDE

The present invention relates to an improved process for preparing L- phenylephrine hydrochloride 3 on an industrial scale by asymmetric hydrogenation as the ke y step and a special sequence of subsequent steps, using [Rh(COD)Cl]2 as catalyst and a chiral, two-pronged phosphine ligand such as (2R, 4...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WOLTER, LIENHARD, KLINGLER, FRANZ DIETRICH, DIETRICH, WOLFGANG
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to an improved process for preparing L- phenylephrine hydrochloride 3 on an industrial scale by asymmetric hydrogenation as the ke y step and a special sequence of subsequent steps, using [Rh(COD)Cl]2 as catalyst and a chiral, two-pronged phosphine ligand such as (2R, 4R)-4-(dicyclohexylphosphino)-2- (diphenylphosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine as the catalys t system.