AZABICYCLOALKANE DERIVATIVES AND THERAPEUTIC USES THEREOF

The present invention is directed to a compound of the formula (I): (see formula I) and pharmaceutically acceptable salts thereof, wherein R1, R2, Y, U, W, k, A , E, V, R4 and R5 are as defined herein, pharmaceutical compositions thereof, and methods of use thereof in the inhibition of serotonin reu...

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Bibliographische Detailangaben
Hauptverfasser:	BUTLER, TODD WILLIAM, FLIRI, ANTON FRANZ JOSEF, GALLASCHUN, RANDALL JAMES
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention is directed to a compound of the formula (I): (see formula I) and pharmaceutically acceptable salts thereof, wherein R1, R2, Y, U, W, k, A , E, V, R4 and R5 are as defined herein, pharmaceutical compositions thereof, and methods of use thereof in the inhibition of serotonin reuptake, the inhibition of the binding of 5-HT2A serotonin receptors and the treatment of diseases, conditions or disorders of the central nervous system . Further, the present invention is also directed to methods for the preparation of compounds of formula (I) and intermediates useful therefor.