INTERMEDIATE FOR THE SYNTHESIS OF AMLODIPINE, A PROCESS FOR THE PREPARATION THEREOF AND CORRESPONDING USE

INTERMEDIATE FOR THE SYNTHESIS OF AMLODIPINE, A PROCESS FOR THE PREPARATION THEREOF AND CORRESPONDING USE

An intermediate for the synthesis of amlodipine, a process for the preparation thereof and the corresponding use are disclosed. The intermediate is ethyl 3-amino-4-(2-(phthalimido)ethoxy)crotonate and is of formula III (See formula III) The process for the preparation thereof comprises reacting the...

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Bibliographische Detailangaben
Hauptverfasser: COPPI, LAURA, CAMPON PARDO, JULIO, GASANZ GUILLEN, YOLANDA
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:An intermediate for the synthesis of amlodipine, a process for the preparation thereof and the corresponding use are disclosed. The intermediate is ethyl 3-amino-4-(2-(phthalimido)ethoxy)crotonate and is of formula III (See formula III) The process for the preparation thereof comprises reacting the acetoacetate of formula (See formula IV) with ammonium acetate, and the use thereof is for the preparation of the compound of formula (See formula V) the process being conducted by reacting ethyl 3-amino-4-[2- (phthalimido)ethoxy]crotonate with a benzylidene derivative