PROCESS FOR THE PREPARATION OF THE MESYLATE SALT TRIHYDRATE OF 1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDIN-1-YL)-1-PROPANOL

PROCESS FOR THE PREPARATION OF THE MESYLATE SALT TRIHYDRATE OF 1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDIN-1-YL)-1-PROPANOL

The present invention is directed to a process for the preparation of the mesylate trihydrate of the (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin -1- yl)-1-propanol compound having the formula (I): (see formula I) The present invention is also further comprises a process for enantiomer...

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Bibliographische Detailangaben
Hauptverfasser: WALINSKY, STANLEY WALTER, SINAY, TERRY GENE JR, RAINVILLE, JOSEPH PHILIP
Format: Patent
Sprache:eng ; fre
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention is directed to a process for the preparation of the mesylate trihydrate of the (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin -1- yl)-1-propanol compound having the formula (I): (see formula I) The present invention is also further comprises a process for enantiomeric resolution and isolation of the (D)-(-)-tartrate salt of the compound of the formula (I).