PROCESS FOR THE PREPARATION OF THE MESYLATE SALT TRIHYDRATE OF 1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDIN-1-YL)-1-PROPANOL AND INTERMEDIATES USEFUL THEREFOR

PROCESS FOR THE PREPARATION OF THE MESYLATE SALT TRIHYDRATE OF 1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDIN-1-YL)-1-PROPANOL AND INTERMEDIATES USEFUL THEREFOR

The present invention is directed to a novel process for the preparation of the mesylate trihydrate of the compound of formula (I), (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol: (see formula I) The present invention is further directed to a process for the preparation...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: WALINSKY, STANLEY WALTER, SINAY, TERRY GENE JR, RAINVILLE, JOSEPH PHILIP
Format: Patent
Sprache:eng ; fre
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present invention is directed to a novel process for the preparation of the mesylate trihydrate of the compound of formula (I), (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol: (see formula I) The present invention is further directed to a process for the preparation o f a (2S)-(+)- compound of formula (II): (see formula II) wherein R1 is a protecting group. In addition, the present invention relates to intermediates useful in said processes.