SYNTHESIS OF ACYCLIC NUCLEOSIDE DERIVATIVES

Novel intermediates and improvements in the synthesis of acyclic guanine nucleoside prodrugs of the formula (R)-9-[(2-alkanoylmethyl)-4- (aminoacyloxy)butyl]guanine (for example valtamociclovir stearate), including purine salts amenable to one pot alkylation with the acyclic side chain, acyclic 2-am...

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Hauptverfasser:	TIAN, ZHENPING, WAYNE, GREG, ZHANG, WEIJIANG, RILEY, DAVID A, CURTY, CYNTHIA B, PLATA, DANIEL, LEANNA, M. ROBERT, PATEL, RAMESH R, LANNOYE, GREG, TIEN, JIEN-HEH J, NARAYANAN, BIKSHANDARKOIL A, SHELAT, BHADRA, CHANG, SOU-JEN, BELLETTINI, JOHN, LUKIN, KIRILL A, RASMUSSEN, MICHAEL, KOLACZKOWSKI, LAWRENCE, HANNICK, STEVEN M, SINGAM, PULLA REDDY, MORTON, HOWARD, BHAGAVATULA, LAKSHMI, YANG, CHENG-XI, GATES, BRADLEY D, SPITZ, TIFFANY
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Novel intermediates and improvements in the synthesis of acyclic guanine nucleoside prodrugs of the formula (R)-9-[(2-alkanoylmethyl)-4- (aminoacyloxy)butyl]guanine (for example valtamociclovir stearate), including purine salts amenable to one pot alkylation with the acyclic side chain, acyclic 2-amino-6-halo-purine and protected guanine precursors, one pot manipulations thereof and last step work up procedures.