ACETYLCHOLINE ENHANCERS

Disclosed herein are quinoline derivatives having dual mechanistic propertie s, referred to in this patent document as "acetylcholine enhancers", i.e., compounds which evidence acetylcholinesterase (AChE) inhibition activity, an d 5-HT3 receptor antagonist activity. A particularly preferre...

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Hauptverfasser:	KODA, TADAYUKI, CHALMERS, DEREK T, SATO, SUSUMO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Disclosed herein are quinoline derivatives having dual mechanistic propertie s, referred to in this patent document as "acetylcholine enhancers", i.e., compounds which evidence acetylcholinesterase (AChE) inhibition activity, an d 5-HT3 receptor antagonist activity. A particularly preferred compound is 2-[ 2- (1-benzylpiperizin-4-yl)ethyl]-2,3-dihydro-9-methoxy-1H-pyrrolo[3,4-b] quinol in- 1-one hemifumarate, referred to herein as Compound A ("Cm.A"). Disclosed herein are quinoline derivatives having dual mechanistic properties, referred to in this patent document as "acetylcholine enhancers", i.e., compounds which evidence acetylcholinesterase (AChE) inhibition activity, and 5-HT3 receptor antagonist activity. A particularly preferred compound is 2-¢2- (1-benzylpiperizin-4-yl)ethyl!-2,3-dihydro-9-methoxy-1H-pyrrolo¢3,4-b!quinolin-1-one hemifumarate, referred to herein as Compound A ("Cm.A").