ADHESIVE APPLICATOR WITH POLYMERIZATION AGENTS AND/OR BIOACTIVE MATERIAL

A method of applying a bioactive agent and/or a polymerization or cross- linking rate modifier and/or a polymerization initiator to an applicator tip includes dissolving or dispersing the rate modifier, the initiator, and/or t he bioactive agent in a low boiling point solvent, applying the resulting solution or dispersion to the applicator tip, and drying the applicator tip. The initiator and/or rate modifier is preferably applied in a methanol solve nt and distributed along a concentration gradient on the applicator tip. A method of applying a bioactive agent and/or a polymerization or crosslinking rate modifier and/or a polymerization initiator to an applicator tip includes dissolving or dispersing the rate modifier, the initiator, and/or the bioactive agent in a low boiling point solvent, applying the resulting solution or dispersion to the applicator tip, and drying the applicator tip. The initiator and/or rate modifier is preferably applied in a methanol solvent and distributed along a concentration gradient on the applicator tip.