BARBITURIC ACID DERIVATIVE AND PREVENTIVE AND THERAPEUTIC AGENT FOR BONE AND CARTILAGE CONTAINING THE SAME

The present invention relates to a barbituric acid derivative shown in formu la (I) (wherein R or R1 independently represents a hydrogen atom, a susbstitute d or not substituted alkyl group or alkenyl group of C1 - C15, a substituted o r not substituted arylmethyl group, and substituted or not substituted aryl group, and R2 represents substituted or not substituted alkyl group or alken yl group of C1 - C15, a substituted or not substituted arylmethyl group, and substituted or not substituted aryl group). The barbituric acid derivative o f the present invention has a strong inhibiting activity to bone resorption an d is useful as a preventive and therapeutic agent for diseases affecting bone and cartilage. The present invention relates to a barbituric acid derivative shown in formula (I) (wherein R or R1 independently represents a hydrogen atom, a susbstituted or not substituted alkyl group or alkenyl group of C1 - C15, a substituted or not substituted arylmethyl group, and substituted or not substituted aryl group, and R2 represents substituted or not substituted alkyl group or alkenyl group of C1 - C15, a substituted or not substituted arylmethyl group, and substituted or not substituted aryl group). The barbituric acid derivative of the present invention has a strong inhibiting activity to bone resorption and is useful as a preventive and therapeutic agent for diseases affecting bone and cartilage.