SUBSTITUTED BISINDOLYMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION

SUBSTITUTED BISINDOLYMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION

Substituted pyrroles of formula (I) wherein R1 is hydrogen and R2 is methyl or R1 is methyl and R2 is hydrogen or R1 is hydroxymethyl and R2 is methyl as well as pharmaceutically acceptable prodrugs or pharmaceutically acceptable salts thereof are antiproliferative agents useful in the treatment of...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WEBER, GIUSEPPE FEDERICO, KE, JUNE, HURYN, DONNA MARY, DHINGRA, URVASHI HOODA
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Substituted pyrroles of formula (I) wherein R1 is hydrogen and R2 is methyl or R1 is methyl and R2 is hydrogen or R1 is hydroxymethyl and R2 is methyl as well as pharmaceutically acceptable prodrugs or pharmaceutically acceptable salts thereof are antiproliferative agents useful in the treatment of cancer.