NOVEL COMPOUNDS

Novel sulphonamide derivatives of formula (I) or a salt thereof having CNS activity, processes for their preparation and their use as medicaments: in which E is -SO2NH- or -NHSO2- P is a phenyl, naphthyl, a bicyclic heterocyclic ring or is a 5 to 7-membered heterocyclic ring each containing 1 to 4 heteroatoms selected from oxygen, nitrogen or sulphur; A is a single bond, a C1-6alkylene or a C1-6alkenylene group; R1 is halogen, C1-6alkyl optionally substituted by one or more fluorine atoms, C3-6cycloalkyl, C1-6alkoxy, OCF3, C1-6alkoxyC1-6alkoxy; C1-6alkanoyl, amino, alkylamino or dialkylamino, SR11 where R11 is hydrogen or C1-6alkyl or R1 is phenyl, benzyl, naphthyl, a bicyclic heterocyclic ring or is a 5 to 7-membered heterocyclic ring each containing 1 to 4 heteroatoms selected from oxygen, nitrogen or sulphur; and n is 0, 1, 2, 3, 4 or 5; R3 is a group R5 or together with R5 forms a group (CH2)2O or (CH2)3O; R4 is selected from a group of formula (i), (ii) or (iii): Formula (i) in which R6 is C1-6alkyl optionally substituted by one or more halogen atoms; m is 0, 1 or 2; q is 0, 1, 2, 3 or 4; or Formula (ii) in which R6, m and q are as defined in formula (i); or Formula (iii) in which R6, and q are as defined in formula (I) and R7 is hydrogen or C1-6alkyl; R5 is hydrogen, halogen, C1-6alkoxy optionally substituted with one or more fluorine atoms, trifluoromethyl, or together with R3 forms a group (CH2)2O or (CH2)3O.