ADVANCED ACTIVE DEVICES AND METHODS FOR MOLECULAR BIOLOGICALANALYSIS AND DIAGNOSTICS

Methods of manufacture and devices for performing active biological operatio ns utilize various structures to advantageously collect and provide charged biological materials to an array of microlocations. In o ne embodiment, a device includes focusing electrodes to aid in the direction and transport...

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Bibliographische Detailangaben
Hauptverfasser:	LECLAIR, TIMOTHY L, ACKLEY, DONALD E, MATHER, ELIZABETH L, BUTLER, WILLIAM F, GRAHAM, SCOTT O, SWANSON, PAUL D
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BASIC ELECTRIC ELEMENTS BEER BIOCHEMISTRY CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR ELECTRICITY ENZYMOLOGY INFORMATION STORAGE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MANUFACTURE OR TREATMENT OF NANOSTRUCTURES MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NANOTECHNOLOGY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SEMICONDUCTOR DEVICES SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES SPIRITS STATIC STORES TESTING TRANSPORTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Methods of manufacture and devices for performing active biological operatio ns utilize various structures to advantageously collect and provide charged biological materials to an array of microlocations. In o ne embodiment, a device includes focusing electrodes to aid in the direction and transport of materials from a collection electrode to a n array. Preferably, one or more intermediate transportation electrodes are utilized, most preferably of monotonically decreasing size between the collection electrode and the array, so as to reduce current density mismatches. In another aspect, a flow cell is utilized over devices to provide containment of solution containing materials to be analyzed. In yet another embodiment, a concentric ring design is provided. Various flip-chip embodiments are disclosed.