SYNERGISTIC ANTIMICROBIAL COMPOSITIONS

Novel antimicrobial compositions and strategy to combat bacterial resistance in a variety of bacterial strains are disclosed. The antimicrobial compositions comprise a combination of mitomycin C, or other reductively activated compounds, and ABPI and/or imino-ABPI. The unique strategy involves exposing microorganisms to a first antimicrobial agent, such as mitomycin C, which can induce the expression of at least one protein which confers resistance to mitomycin C, i.e., inactivates mitomycin C. Simultaneously or soon thereafter, the microorganisms are exposed to a second antimicrobial agent, such as ABPI and/or imino-APBI, which is activated by the same protein which inactivates the first antimicrobial agent.